Smoking Gun: Days of Wine and Roses

Gravity’s Smoking Gun?

We present a new constraint on the biased galaxy formation picture. Gravitational instability theory predicts that the two-point mass density correlation function, ξ(r), has an inflection point at the separation r = ro, corresponding to the boundary between the linear and nonlinear regime of clustering, ξ ≃ 1. We show how this feature can be used to constrain the biasing parameter, b ≡ ξg(r)/ξ(...

The smoking gun of eugenics

Editorial: Aluminum – Alzheimer's Smoking Gun?

It is becoming apparent that with an aging population comes an increase in the incidence of mental impairment. In death certificates of people over 75 years of age, the number listed as having dementia has increased by a factor of 20 in the last 15 years (Forbes, Lessard, & Gentleman, 1995, appearing in the present issue). Most of this increase is probably the result of heightened diagnostic se...

Smoking Gun or Red Herring

In this issue of Circulation Research, Zhang et al1 provide direct and clear evidence that phosphorylation of S2808 in the cardiac ryanodine receptors (RyR2) has no impact on either normal cardiac function, sympathetic stimulation of the heart, or progression of heart failure (HF) after myocardial infarction (MI). They used mice in which the S2808 site was rendered nonphosphorylatable in S2808A...

Obesity, PANDAS, Smoking, and Gun Violence.

This issue of Pediatric Annals is devoted to pediatric gastroenterology and is guest edited by Dr. Vincent F. Biank. The article topics range from Crohn’s disease to eosinophilic esophagitis to failure to thrive, pancreatitis, and nonalcoholic steatohepatitis, and will be useful to primary care providers. In this editorial, I cover several topics that I feel are of interest to the readership, i...